Promoter hypermethylation patterns of P16, DAPK and MGMT in Oral Squamous Cell Carcinoma: A systematic review and meta-analysis.
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Date
2014-11
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Abstract
Background: Oral squamous cell carcinoma (OSCC) is a common cancer world‑wide that is highly
lethal due to its recurrence and metastasis. Methylation is a common epigenetic mechanism that
leads to gene silencing in tumors and could be a useful biomarker in OSCC. The prevalence of P16,
death‑associated protein kinase (DAPK) and O6‑methylguanine‑DNA‑methyltransferase (MGMT)
promoter hypermethylation in OSCC has been evaluated for several years while the results
remain controversial.
Objective: The aim of this systematic review is to critically analyze and perform a meta‑analysis
on the various studies in the literature that have reported the promoter hypermethylation of
P16, DAPK and MGMT genes in OSCC.
Search Strategy: Articles were searched and selected through PubMed. Hand search from the
relevant journals was also performed. Articles were reviewed and analyzed.
Results: The estimated prevalence of P16 methylation was 43%, DAPK methylation was 39.7%
and MGMT methylation was 39.8%. Heterogeneity in methylation prevalences and correlations
with the clinical outcomes of the disease prevailed in various studies.
Conclusion: We can conclude from our systematic review that a higher prevalence of methylation
of P16, DAPK and MGMT occur in OSCC. Further studies are required to substantiate the role
of methylation of P16, DAPK and MGMT as a marker in OSCC.
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Keywords
Death‑associated protein kinase, O6‑methylguanine‑DNA‑methyltransferase, oral squamous cell carcinoma, P16, promoter hypermethylation
Citation
Don K R, Ramani Pratibha, Ramshankar Vijayalakshmi, Sherlin Herald Justin, Premkumar Priya, Natesan Anuja. Promoter hypermethylation patterns of P16, DAPK and MGMT in Oral Squamous Cell Carcinoma: A systematic review and meta-analysis. Indian Journal of Dental Research. 2014 Nov-Dec ; 25 (6): 797- 805.