Allogeneic haematopoietic stem cell transplantation: The Army hospital experience.
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Date
2013-01
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Abstract
Background. We analysed the results of allogeneic
haematopoietic stem cell transplantation (HSCT) in various
genetic disorders, bone marrow failures and haematological
malignancies done from 2002 to 2010 at the Army Hospital,
Research and Referral, Delhi.
Methods. A total of 119 matched-related allogeneic-
HSCTs (allo-HSCTs) were done in 114 patients (men 76,
women 38) aged between 2 and 60 years. Peripheral blood
stem cells (n=75) and bone marrow (n=43) were used as the
source of stem cells.
Results. The overall survival was 62.3% (71/114) at a
median follow-up of 34 months. Graft versus host disease
(GVHD) was seen in 42 (36.8%) patients; grade III/IV acute
GVHD in 17 (15%) and chronic GVHD in 24 (21%)
patients. There were 4 (3.5%) graft rejections and one nonengraftment.
The overall mortality was 37.7% (n=43) and
the main causes of death were GVHD (32%), infections
(26%), relapse (23%) and regimen-related toxicity (11%).
Conclusion. Our results are comparable to published data
in most disease conditions. With improvements in GVHD
prophylaxis and better supportive care, we need to further
reduce our mortality and morbidity.
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NAIR V, SHARMA A, DAS S, SHARMA S, GROVER N, KAUR J. Allogeneic haematopoietic stem cell transplantation: The Army hospital experience. National Medical Journal of India. 2013 Jan-Feb ; 26 (1): 6-11.