Role of Vitamin-D in the prevention and treatment of Alzheimer’s disease.
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Date
2015-01
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Abstract
Alzheimer’s disease is the most common form of age related cognitive impairment. Aim of the present study
was to see the effect of vitamin D on cognitive function in elderly. The study was conducted in Department
of Physiology, King George’s Medical University (KGMU). A total of 80 subjects were enrolled based on Mini
Mental State Examination (MMSE) score < 24 and vitamin D deficiency. They were divided into two groups
as Group A (case) and Group B (control), each group having 40 subjects. Intervention (Vitamin D
supplementation) was given in Group A. The assessment of dementia was done by Mini Mental State
Examination (MMSE) score. Every subject was clinically evaluated and estimation of vitamin D was done
by direct ELISA kit. Gender, weight, height, BMI, residence and education were also similar between two
groups. A significant (p=0.0001) change in MMSE score was observed in both Group A and Group B from
baseline to 3 & 6 months and from 3 to 6 months, however, mean change was higher in Group A than Group
B. In conclusion, vitamin D supplementation caused significant improvement in the cognitive performance in
subjects with senile dementia.
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Gangwar Anil Kumar, Rawat Anita, Tiwari Sunita, Tiwari S C, Narayan Jagdish, Tiwari Sanchit. Role of Vitamin-D in the prevention and treatment of Alzheimer’s disease. Indian Journal of Physiology and Pharmacology. 2015 Jan-Mar ; 59 (1) : 94-99.