Correlation between lipid profile & carotid intima media thickness in cerebral ischemia.
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Date
2014-10
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Abstract
Cerebrovascular accident or stroke is defined by an abrupt onset of neurological deficit that is attributable
to a focal vascular cause. Stroke is a major cause of morbidity and mortality worldwide. This may result
from brain infarction or hemorrhage. Carotid atherosclerosis is a reasonable risk factor for cerebral ischemic
stroke. Deranged lipid metabolism due to various modifiable and non-modifiable risk factors leads to the
pathogenesis of atherosclerosis. This study is intended to find out any association between altered lipid
metabolism (Cholesterol, Triglycerides, LDL : HDL ratio) and development of cerebral ischemia. An observational
case control study was conducted with 50 cases of cerebral ischemia and 50 age & sex matched healthy
controls within age group 50-70 years. After inclusion of cases and controls and taking informed consent
they underwent history taking, proper clinical examination &biochemical investigations (lipid profile). Then
data were collected and results were statistically analyzed using Chi-square test & Independent Sample “Ttest”.
The study showed altered lipid profile is associated with cerebral ischemia by increasing carotid intima
media thickness (IMT). There was significant (p<0.001) dyslipidemia (NCEP ATP III guidelines) in cases as
compared to controls. Hence early diagnosis and monitoring of dyslipidemia and treatment of the high risk
group with anti hyperlipidemic drugs will help to prevent the incidence of cerebral ischemic stroke thereby
reducing morbidity and mortality.
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Sengupta Debalina, Bardhan Jayati, Mahapatra Anil Baran Singha, Banerjee Joyshree, Rout Jayanta Kumar. Correlation between lipid profile & carotid intima media thickness in cerebral ischemia. Indian Journal of Physiology and Pharmacology. 2014 Oct-Dec ; 58 (4) : 354-364.