Beneficial effect of Omega-3 polyunsaturated fatty acids on neurosensorial impairments and oxidative status in Streptozotocin induced diabetic rats.
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Date
2014-10
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Abstract
Objectives: The present study evaluated the beneficial effects of omega 3 PUFA present in fish oil on
neurosensorial impairments, namely learning, memory and anxiety in Streptozotocin (STZ) induced diabetic
rats. The brain homogenate was analysed for oxidative status following Omega 3 PUFA treatment.
Methods: Male, Wistar rats of 2-3 months old were divided into non diabetic controls, diabetic control, &
fish oil treated diabetic rats (n=6). Diabetes was induced by injection of STZ (48 mg/kg, ip). Animals were
treated orally for 30 days with a dose in each group of 0.5 g/kg/day of fish oil. All experiments were
conducted after ethical committee clearance was obtained.
Results: Memory and exploratory behavior were improved (p<0.01) in fish oil treated rats as compared with
diabetic rats. A significant (p<0.001) decrease in MDA and a significant increase (p<0.001) in total antioxidant
level (TAO) were observed in fish oil treated rats.
Conclusion : Omega 3 PUFA present in fish oil could be used an adjuvant therapy for treatment and
prevention of neurosensorial impairment in diabetes mellitus.
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Yadav Saraswati, Mitha K V, Shenoy Mamatha T, Mayannavar Santhosh, Ganaraja B. Beneficial effect of Omega-3 polyunsaturated fatty acids on neurosensorial impairments and oxidative status in Streptozotocin induced diabetic rats. Indian Journal of Physiology and Pharmacology. 2014 Oct-Dec ; 58 (4) : 346-353.