A case of extended spectrum beta-lactamase producing Salmonella enterica serotype paratyphi A from India.
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Date
2015-01
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Abstract
Enteric fever caused by Salmonella enterica is a systemic infection with high rates
of morbidity and mortality. Increasing antibiotic resistance in S. enterica has led to
shift in the choice of antibiotics used against this organism from chloramphenicol
and ampicillin to trimethoprim-sulfamethoxazole, fl uoroquinolones, and extendedspectrum
cephalosporins. Resistance to cephalosporins, due to the production of
extended-spectrum beta-lactamases (ESBLs), is the cause of serious concern
worldwide. So far, these enzymes have been detected in many species of the
family Enterobacteriaceae including different serotypes of S. enterica. To the
best of our knowledge, however, ESBL production in Salmonella Paratyphi A has
not yet been reported from India. We present here a case of ESBL producing
Salmonella Paratyphi A from India. This is a worrisome fi nding with grave clinical
implications, since the dissemination of this resistance trait would further limit
the therapeutic options available for the treatment of enteric fever.
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Keywords
Extended spectrum beta-lactamase, India, Salmonella enterica subspecies enterica serotype paratyphi A
Citation
Roy Priyamvada, Rawat Deepti, Malik Sonia. A case of extended spectrum beta-lactamase producing Salmonella enterica serotype paratyphi A from India. Indian journal of pathology& Microbiology 2015 Jan-Mar 58: (1) 113-114.