Central nervous system mycosis: Analysis of 10 cases.
Loading...
Date
2014-10
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Aim: To describe the clinicopathological features in patients with fungal
infections of the central nervous system (CNS) presenting as mass lesions.
Materials and Methods: A retrospective analysis of records obtained from
10 patients was done with histopathologically confirmed fungal infections
presenting as ICSOL, diagnosed in the department of pathology. Clinical
features at presentation, findings of radiological investigations performed
and histopathology were noted for each patient and subjected for analysis.
Results: Infection was higher in males, and paranasal sinusitis was
the most common predisposing factor. Location was intraparenchymal
followed by sphenoid wing. Four dural-based lesions mimicked meningioma
clinically. The most common fungus identified was zygomycosis (seven
cases), followed by phaeohyphomycosis (two cases) and aspergillosis
(one case). Conclusion: There is a rising trend of CNS mycosis, both in
immunocompromised and immunocompetent patients. Intracranial fungal
granuloma may mimic radiologically as glioma or meningioma, therefore
a high index of suspicion is needed to detect early CNS fungal infections,
especially in immunocompetent young patients with no predisposing
illness. Fungi should always be excluded in patients with inflammatory or
granulomatous pathology of CNS.
Description
Keywords
Aspergillosis, CNS Mycosis, phaeohyphomycosis, zygomycosis
Citation
Shukla Anju, Bansal Megha, Husain Mazhar, Chhabra Devendra Kumar. Central nervous system mycosis: Analysis of 10 cases. Indian Journal of Pathology & Microbiology. 2014 Oct-Dec 57 (4): 591-594.