Association of Ki-67 antigen and p53 protein at invasive tumor front of oral squamous cell carcinoma.
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Date
2014-10
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Abstract
Aim: Studies reveal that invasive tumor front may be the best field for
quantifi cation of proliferative and apoptotic markers. The current study assessed
the expression of Ki-67 antigen and p53 protein at invasive tumor front of oral
squamous cell carcinoma (OSCC) and correlated the immunostaining with the
histologic grades of malignancy. Materials and Methods: A total of 80 slides
sample was prepared for the study, one each from ten normal oral mucosa
cases and two each from 30 OSCC cases. The OSCC patients were biopsied
along invasive tumor front, and samples were immunohistochemically analyzed
for the expression of both Ki-67 antigen and p53 protein. Results: Of the
total 30 OSCC cases, the expression of p53 was found positive in 20 cases
(66.6%), while Ki-67 expression was found positive in 21 cases (70%). All the
cases in the control group were negative. A higher p53 and Ki-67 expression
were seen in OSCC group as compared to normal mucosa. On comparing
the control group with various grades of OSCC a statistically signifi cant result
was obtained. Conclusion: Higher and statistically signifi cant expression was
noted for both p53 and Ki-67 antigen. The results emphasize the potential of
Ki-67 and p53 as biomarkers of carcinogenesis in OSCC. Ki-67 expression was
comparatively higher when compared with p53 except in poorly differentiated
squamous cell carcinoma and signifi es actively proliferating malignant cells at
invasive tumor front.
Description
Keywords
Invasive tumor front, Ki-67 antigen, oral squamous cell carcinoma, p53 protein
Citation
Verma Ruchita, Singh Anil, Jaiswal Rohit, Chandra Akhilesh, Verma Renuka, Tak Jalaj. Association of Ki-67 antigen and p53 protein at invasive tumor front of oral squamous cell carcinoma. Indian Journal of Pathology & Microbiology. 2014 Oct-Dec 57 (4): 553-557.