Epstein - Barr virus-associated lymphoepithelioma-like gastric carcinoma located on gastric high body: Two case reports.
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Date
2014-07
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Abstract
Lymphoepithelioma-like gastric carcinoma (LELGC) is a rare neoplasm of the
stomach with an incidence of 1-4% of all gastric cancers. It is characterized
by the presence of a lymphoid stroma with cells arranged primarily in micro
alveolar, thin trabecular, and primitive tubular patterns or isolated cells. It is
one of the histological patterns observed in patients with Epstein — Barr virus
(EBV)-associated gastric carcinoma (EBVaGC). In situ hybridization was usually
used to confirm the presence of EBV. There are two types of EBVaGC, LELGC,
and ordinary type. Approximately, 15-25% of EBVaGC exhibit the LELGC
pattern. Here, we described two cases of LELGC and the related literatures
were reviewed as well. The two cases were submucosal mass from a 59- or
63-year-old man. We found LELGC has special clinicopathologic features and
protein expression profile. This should promote us to make a true diagnosis.
Description
Keywords
DNMT1, Epstein — Barr virus, gastric carcinoma, immunohistochemistry, lymphoepithelioma-like gastric carcinoma
Citation
Bai Yanfeng, Gao Qiqi, Ren Guoping, Wang Bo, Xiang Hua. Epstein - Barr virus-associated lymphoepithelioma-like gastric carcinoma located on gastric high body: Two case reports. Indian Journal of Pathology & Microbiology. 2014 Jul-sept 57 (3): 463-466.