Loss of chromosome Y in acute lymphoblastic leukemia: Age related or neoplastic phenomenon.
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Date
2014-07
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Abstract
Loss of chromosome Y (LOY) in the bone marrow has long been considered
as an age-related phenomenon with an incidence of more than 25% in males
beyond the age of 80 years. Though reported as an acquired abnormality in
myeloid neoplasms, it has rarely been described in B-lymphoblastic leukemia
which primarily is a disease of the young. We describe here in three cases of
pediatric B-lymphoblastic leukemia with LOY. Conventional cytogenetic studies
and fluorescence in situ hybridization studies using centromeric probes for
chromosome X and Y on peripheral blood samples ruled out constitutional LOY
in all the three cases favoring it to be a neoplastic phenomenon.
Description
Keywords
Acquired abnormality, B-lymphoblastic leukemia, loss of chromosome Y, pediatric
Citation
Gupta Anurag, Parihar Mayur, Remani Arun S, Mishra Arun S. Loss of chromosome Y in acute lymphoblastic leukemia: Age related or neoplastic phenomenon. Indian Journal of Pathology & Microbiology. 2014 Jul-sept 57 (3): 431-434.