Prevalence of extended spectrum beta-lactamase producing uropathogens and their antibiotic resistance profile in patients visiting a tertiary care hospital in central India: Implications on empiric therapy.
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Date
2014-07
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Abstract
Context: Antimicrobial resistance showed by different uropathogens is one of
the barricades that might hinder a successful treatment. Detection of extended
spectrum beta-lactamase (ESBL) production among uropathogens is an
important marker of endemicity. Aims: The present prospective study was
done to identify the trends of uropathogens, to find the prevalence of ESBL
isolates and to study the antibiotic resistance profile of the ESBL and non-ESBL
uropathogenic isolates. Materials and Methods: This study was conducted in
the Department of Microbiology of a teaching tertiary care hospital from July 2013
to September 2013. All the uropathogenic isolates were identified up to species
level by conventional methods. The prevalence of potential ESBL producers
was explored. Antibiotic resistance test of the urinary isolates was done by
disc-diffusion method and the results were interpreted according to Clinical
Laboratory Standards Institute-2013 guidelines. Results: A total of 670 urine
samples from male and female patients visiting the outpatient department (OPD)
and inpatient department (IPD) of our hospital were collected. A significantly
higher number of IPD and OPD males (55.1% and 55.5%) were found to be
culture positive. Escherichia coli (55.3%) was the most frequently isolated
uropathogen followed by Klebsiella pneumoniae (23%). However, strains of
Escherichia coli (41.6%) were the highest ESBL producing isolates followed
by Pseudomonas aeruginosa (36.1%). ESBL producing isolates were found
to be multidrug-resistant when compared to non-ESBL producers. However,
excessive drug-resistance among non-ESBL producing isolates can’t be ignored.
Conclusion: Our study confirms a global trend toward increased resistance to
beta-lactam antibiotics. We emphasize on the formulation of antibiotic policy for
a particular geographical area.
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Keywords
Beta-lactam antibiotics, extended spectrum beta-lactamase, uropathogens
Citation
Bajpai Trupti, Pandey Maneesha, Varma Meena, Bhatambare Ganesh S. Prevalence of extended spectrum beta-lactamase producing uropathogens and their antibiotic resistance profile in patients visiting a tertiary care hospital in central India: Implications on empiric therapy. Indian Journal of Pathology & Microbiology. 2014 Jul-sept 57 (3): 407-412.