Your dilemma, my identity: Unusual immunogenetic profiles of pediatric B cell acute lymphoblastic leukemia.
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Date
2014-01
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Abstract
B-cell acute lymphoblastic leukemia (B-ALL) is characterized by CD19 expression,
which is one of the most important prerequisites, along with expression of CD10,
CD22 and/or CD79a. Rearrangements involving MLL gene are seen in CD10−
B-ALL (pro-B cell origin) and t(9;11)(p21;q23) is most commonly reported in
acute myeloid leukemia (AML), where it is known to carry very good prognosis
in pediatric AMLs and rarely in acute lymphoblastic leukemia (ALL). We report a
case of CD10+, CD19− pediatric ALL with rearrangements of MLL gene as a result
of t(9;11)(p21;q23), thus conferring a very poor prognosis. The case emphasizes
use of comprehensive panel of antibodies for fl ow cytometric immunophenotyping
and cytogenetic correlation for correct diagnosis and prognostication.
KEY WORDS: Acute lymphoblastic leukemia, CD19, MLL gene, t(9;11)(p21;q23)
Description
Keywords
Acute lymphoblastic leukemia, CD19, MLL gene, t(9;11)(p21;q23)
Citation
Gupta Anurag, Goyal Manu, Nidamanuri Koteswara Rao, Dattatreya Palanki Satya. Your dilemma, my identity: Unusual immunogenetic profiles of pediatric B cell acute lymphoblastic leukemia. Indian Journal of Pathology & Microbiology. 2014 Jan-Mar 57 (1): 78-80.