Cytohistological correlation in diagnosis of lung tumors by using fiberoptic bronchoscopy: Study of 200 cases.
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Date
2013-04
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Abstract
Background: Examination of specimens obtained through fl exible fi beroptic
bronchoscope is an important and often the initial diagnostic technique
performed in patients with suspected malignant lung lesion. Aims: To evaluate
the correlation of cytological fi ndings of bronchial washings, bronchial brushing
and imprint smear of bronchial biopsy in the diagnosis of lung tumors, with
histopathology of bronchial biopsy taking the latter as the confi rmatory diagnostic
test. Materials and Methods: A total of 200 patients with lung mass were
included in the study. Bronchial brushings were obtained from all 200 cases.
In the fi rst 100 cases, pre-biopsy bronchial washing (washing collected before
the brushing and biopsy procedure) while post-biopsy washing (washing at
the end of the procedure) was procured in all 200 cases. Imprint smears of
bronchial biopsy were prepared in 150 cases. Results: Sensitivity and specifi city
of brushing was 76.58% and 77.78% respectively and that of imprint smear
was 81.35% and 78.12% respectively. Pre-biopsy and post-biopsy washing
showed high specifi city of 88.89%, but low sensitivity of 30.14 and 36.77%
respectively. No signifi cant difference was found in sensitivity between brushing
and imprint smear (Chi-square; P = 0.4187); and between pre-biopsy and postbiopsy
washing (Chi-square; P = 0.7982). However, there was a signifi cant
difference between sensitivity of brushing and washing (Chi-square; P = 0.0001).
The sensitivity of combination of three cytological diagnostic techniques was
87.29%. Conclusion: Bronchial brushing and washing cytology in combination
with imprint cytology aids in the diagnosis of lung tumors. Therefore, all these
techniques may be used concurrently along with bronchial biopsy to diagnose
lung tumors.
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Keywords
Bronchial washing, brushing, fi beroptic bronchoscopy, imprint smear, lung cancer
Citation
Bodh Anita, Kaushal Vijay, Kashyap Surender, Gulati Anchna. Cytohistological correlation in diagnosis of lung tumors by using fiberoptic bronchoscopy: Study of 200 cases. Indian Journal of Pathology & Microbiology. 2013 Apr-Jun 56(2): 84-88.