Diurnal variation in central corneal thickness and intraocular pressure in eyes with pseudoexfoliation syndrome without glaucoma.
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Date
2014-11
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Abstract
Aim: The aim was to ascertain if any differences exist in diurnal central corneal thickness (CCT) and
intra‑ocular pressure (IOP) between eyes with pseudoexfoliation (PXF) syndrome without glaucoma
and eyes with no ocular pathology. A secondary aim was to determine whether there was a significant
relationship between CCT and IOP. Settings and Design: This study was a prospective design conducted
within a hospital setting. Materials and Methods: The experimental group consisted of seven participants
with bilateral PXF (14 eyes) and the control group comprised of 15 participants (30 eyes). Testing included
CCT and IOP measured at four different times on one given day (8.00 a.m.; 11 a.m.; 2 p.m. and 5 p.m.).
Statistical Analysis: The data were analyzed with the generalized linear latent mixed model. Results:
PXF eyes displayed a significantly thinner overall mean CCT (520 μm) compared to controls (530 μm).
Furthermore, a significant reduction in CCT and IOP occurred in the PXF group from 8 a.m. to 5 p.m. The
mean overall IOP in PXF eyes was significantly lower than the control group. A significant association
between IOP and CCT was also found in PXF eyes. Conclusions: Displaying a significantly thinner mean
CCT highlights the importance of measuring CCT in an ophthalmic clinical setting as to avoid falsely
underestimated IOP measurements in such a high‑risk glaucoma population. Furthermore, a statistically
significant correlation between IOP and CCT in PXF eyes suggests that the reduction in CCT that occurred
in PXF eyes between 8 a.m. and 5 p.m. may be partly responsible for the reduction in IOP measurements.
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Keywords
Central corneal thickness, diurnal variation, glaucoma, intra‑ocular pressure, pseudoexfoliation syndrome
Citation
Keel Stuart, Malesic Linda, Chan Siew Pang. Diurnal variation in central corneal thickness and intraocular pressure in eyes with pseudoexfoliation syndrome without glaucoma. Indian Journal of Ophthalmology. 2014 Nov ; 62 (11): 1072-1076.