Choroidal thickness profile in healthy Indian subjects.
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Date
2014-11
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Abstract
Purpose: The aim was to study choroidal thickness (CT) and its profile based on location in healthy Indian
subjects using Cirrus high definition (HD) optical coherence tomography. Materials and Methods: A total
of 211 eyes of 115 healthy subjects with no retinal or choroidal disease were consecutively scanned using
Cirrus HD 1 line raster scan mode without pupillary dilation. Eyes with any ocular disease or axial
length (AXL) >24 mm or <20 mm were excluded. Experienced technician measured CT from the lower
border of the retinal pigment epithelium (RPE) to the lower border of choroid. CT was measured from the
posterior edge of the RPE to the choroid/sclera junction at 500‑μm intervals up to 3000 μm temporal and
nasal to the fovea. Generalized estimating equations were used to evaluate the correlation between CT
at various locations and age, AXL, spherical equivalent, and macular thickness. Results: Mean age was
42.8 ± 13.6 years. Mean AXL was 22.84 ± 0.78 mm. Median spherical equivalent was 0.16 ± 0.64 D. Mean
central macular thickness was 216.4 ± 30.03 μm. Choroidal was thinnest nasally and thickest subfoveally. On
multivariate regression, age was the most significant factor affecting subfoveal CT (P = 0.000). Regression
analysis showed an approximate decrease in CT of 1.18 μm every year. Conclusions: Our study provides
CT profile in Indian healthy subjects in various age groups. CT depends on its location, subfoveal being the
thickest and nasal being the thinnest. Age is a critical factor, which is negatively correlated with CT.
Description
Keywords
Choroid, choroidal thickness, enhanced depth imaging
Citation
Chhablani Jay, Rao P Srinivasa, Venkata Amarnath, Rao Harsha L, Rao B Siva Koteswar, Kumar Uday, Narayanan Raja, Pappuru Rajeev Reddy. Choroidal thickness profile in healthy Indian subjects. Indian Journal of Ophthalmology. 2014 Nov ; 62 (11): 1060-1063.