Comparing acromegalic patients to healthy controls with respect to intraocular pressure, central corneal thickness, and optic disc topography findings.
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Date
2014-08
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Abstract
Aims: The aim was to compare the intraocular pressure (IOP), central corneal thickness (CCT), and optic disc
topography fi ndings of biochemically controlled acromegalic patients and the control group and to evaluate
the eff ect of the duration of acromegaly and serum growth hormone and insulin-like growth factor-1 (IGF-1)
levels on these ocular parameters. Materials and Methods: IOP measurement with Goldmann applanation
tonometry, CCT measurement with ultrasonic pachymetry, and topographic analysis with Heidelberg
retinal tomograph III were performed on 35 biochemically controlled acromegalic patients and 36 age- and
gender-matched controls. Results: Mean IOP and CCT were 14.7 ± 2.9 mmHg and 559.5 ± 44.9 m in
the acromegaly patients and 13.0 ± 1.6 mmHg and 547.1 ± 26.7 m in controls (P = 0.006 and P = 0.15,
respectively). A signifi cant moderate correlation was found between the duration of acromegaly and
CCT (r = 0.391) and IOP (r = 0.367). Mean retinal nerve fi ber layer (RNFL) thickness was signifi cantly lower
in the acromegalic patients (0.25 ± 0.05 mm) as compared to controls (0.31 ± 0.09 mm) (P = 0.01). A signifi cant
moderate correlation was detected between IGF-1 level and disc area (r = 0.362), cup area (r = 0.389) and cup
volume (r = 0.491). Conclusion: Biochemically controlled acromegalic patients showed signifi cantly higher
CCT and IOP levels and lower RNFL thickness compared to healthy controls and the duration of disease
was correlated with CCT and IOP levels.
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Keywords
central corneal thickness, intraocular pressure, optic disc topography, retinal nerve fi ber layer thickness
Citation
Sen Emine, Tutuncu Yasemin, Elgin Ufuk, Balikoglu Yilmaz Melike, Berker Dilek, Nur Aksakal F, Ozturk Faruk, Guler Serdar. Comparing acromegalic patients to healthy controls with respect to intraocular pressure, central corneal thickness, and optic disc topography findings. Indian Journal of Ophthalmology. 2014 Aug ; 62 (8): 841-845.