Post penetrating keratoplasty glaucoma: Cumulative effect of quantifiable risk factors.
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Date
2014-05
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Abstract
Purpose: To ascertain the incidence, identify risk factors and calculate cumulative eff ect of risk factors in
patients developing glaucoma following optical penetrating keratoplasty. Materials and Methods: We
carried out retrospective analysis of 445 patients, those underwent optical PK and had a minimum follow
up of 6 m. Data on post-operative intra-ocular pressure (IOP) recorded at 3, 6, 9, 12 and 18 m or more was
analyzed. Various risk factors including age, sex, indications for penetrating keratoplasty, pre-existing
glaucoma and type of surgical procedures performed were analyzed by using univariate analysis and logistic
regression technique. Results: Ninety (21%) of eyes developed post-PK glaucoma. On applying logistic
regression, age, sex, indication of surgery, pre-existing glaucoma were found to be signifi cant risk factors for
the development of post-PK glaucoma (P < 0.05). Using logistic regression equation the cumulative risk of
developing post-PK glaucoma in an individual patient can be calculated. Conclusions: Male patients, aged
more than 40 years, having opaque grafts as an indication and with pre-existing glaucoma were found to be
higher risk of developing post-PK glaucoma. Patients at higher cumulative risk for development of post-PK
glaucoma may be closely monitored during follow-up.
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Keywords
Glaucoma, intraocular pressure, penetrating keratoplasty, post-PK glaucoma
Citation
Sharma Ashok, Sharma Suresh, Pandav Surinder S, Mohan Kanwar. Post penetrating keratoplasty glaucoma: Cumulative effect of quantifiable risk factors. Indian Journal of Ophthalmology. 2014 May ; 62 (5): 590-595.