Retinal nerve fiber layer thickness in normal Indian pediatric population measured with optical coherence tomography.
Loading...
Date
2014-04
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Purpose: To measure the peripapillary retinal nerve fiber layer (RNFL) thickness in normal Indian pediatric
population. Subjects and Methods: 120 normal Indian children ages 5-17 years presenting to the Pediatric
Clinic were included in this observational cross‑sectional study. RNFL thickness was measured with stratus
optical coherence tomography (OCT). Children with strabismus or amblyopia, with neurological, metabolic,
vascular, or other disorders and those with abnormal optic discs were excluded. One eye of each subject was
randomly selected for statistical analysis. The effect of age, refraction and gender on RNFL thickness was
investigated statistically. Result: OCT measurements were obtained in 120 of 130 (92.3%) subjects. Mean age
was 10.8 ± 3.24 years (range 5-17). Average RNFL thickness was (± SD) 106.11 ± 9.5 μm (range 82.26‑146.25).
The RNFL was thickest inferiorly (134.10 ± 16.16 μm) and superiorly (133.44 ± 15.50 μm), thinner
nasally (84.26 ± 16.43 μm), and thinnest temporally (70.72 ± 14.80 μm). In univariate regression analysis,
age had no statistical significant effect on RNFL thickness (P = 0.7249) and refraction had a significant effect
on RNFL thickness (P = 0.0008). Conclusion: OCT can be used to measure RNFL thickness in children.
Refraction had an effect on RNFL thickness. In normal children, variation in RNFL thickness is large. The
normative data provided by this study may assist in identifying changes in RNFL thickness in Indian
children.
Description
Keywords
Imaging in glaucoma, optical coherence tomography, pediatric, retinal nerve fiber layer
Citation
Pawar Neelam, Maheshwari Devendra, Ravindran Meenakshi, Ramakrishnan Renagappa. Retinal nerve fiber layer thickness in normal Indian pediatric population measured with optical coherence tomography. Indian Journal of Ophthalmology. 2014 Apr ; 62 (4): 412-418.