Repeated bevacizumab injections versus mitomycin C in rotational conjunctival flap for prevention of pterygium recurrence.
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Date
2014-04
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Abstract
Aims: To evaluate the efficacy of repeated bevacizumab injection in rotational conjunctival flap surgery
versus rotational conjunctival flap with adjunctive mitomycin C (MMC) or rotational conjunctival flap
alone. Materials and Methods: Ninety eyes of 90 patients who underwent primary pterygium surgery
with rotational flap were evaluated. Patients were randomly assigned to undergo conjunctival rotational
flap alone (Group A) or conjunctival rotational flap with either 0.02% MMC application (Group B) or
adjunctive subconjunctival 2.5 mg/0.1 ml bevacizumab injection (Group C). Each group consisted of 30 eyes.
Recurrence rates at 9 months were evaluated. Results: There were no statistically significant differences in
mean size of the pterygium across the limbus in terms of length (P > 0.5). The recurrence rates at 9 months
were 26.6% (n = 8) in Group A, 13.3% (n = 4) in Group B, and 10% (n = 3) in Group C. The recurrence rates in
Group B and C were significantly lower than in Group A (P = 0.1806). The recurrence rates were similar in
Group B and C (P > 0.05). Conclusions: Subconjunctival bevacizumab injection may decrease the recurrence
rate of primary pterygium surgery with rotational conjunctival flap. Further studies with a larger population
and longer follow‑up period are needed to supplement this study.
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Keywords
Mitomycin C, pterygium recurrence, pterygium surgery, subconjunctival bevacizumab injection
Citation
Ozsutcu Mustafa, Ayintap Emre, Akkan Julide C U, Koytak Arif, Aras Cengiz. Repeated bevacizumab injections versus mitomycin C in rotational conjunctival flap for prevention of pterygium recurrence. Indian Journal of Ophthalmology. 2014 Apr ; 62 (4): 407-411.