Brachytherapy of intra ocular tumors using ‘BARC I-125 Ocu-Prosta seeds’: An Indian experience.
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Date
2014-02
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Abstract
Aim: To report our experience of brachytherapy using ‘BARC I‑125 Ocu‑Prosta seeds’ for the management
of intraocular tumors with regard to tumor control, globe preservation visual outcome, and patient survival
at Sankara Nethralaya, Chennai, India between September 2003 and May 2011. Materials and Methods: We
reviewed records of 35 eyes of 35 patients who underwent ophthalmic brachytherapy between September 2003
and May 2011. Twenty‑one cases had choroidal melanoma, nine had childhood retinoblastoma, two had
adult‑onset retinoblastoma, and there were one case each of vasoproliferative tumor, retinal angioma, and
ciliary body melanoma. Brachytherapy was administered using a 15‑ or 20‑mm gold plaque with or without
a notch. Brachytherapy was the primary treatment modality in all tumors other than retinoblastoma, wherein
brachytherapy was done post chemoreduction for residual tumor. Results: For choroidal melanomas, the
mean radiation dose was 68.69 ± 15.07 (range, 47.72-94.2) Gy. The eye salvage rate was 13/20 (65%) and
tumor control rate was 16/20 (80%) at an average follow‑up of 24.43 ± 24.75 (range, 1.5-87.98) months. For
retinoblastoma, the mean dose was 45.85 ± 3.90 (range, 39.51-50.92) Gy. The eye salvage rate and tumor
control rate was 5/6 (83.3%) at an average follow‑up of 38.36 ± 31.33 (range, 4.14-97.78) months. All eyes with
retinoblastoma needed additional focal therapy for tumor control and eye salvage. Conclusion: The results of
this retrospective study confirms that the use of ‘BARC I‑125 Ocu‑Prosta seeds’ in episcleral plaques to treat
intraocular tumors offers a viable option for the management of intraocular cancers.
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Keywords
BARC I‑125 Ocu‑Prosta seeds’, choroidal melanoma, ciliary body melanoma, Episcleral plaque brachytherapy, retinal angioma, retinoblastoma, vasoproliferative tumor
Citation
Khetan Vikas, Gopal Lingam, Shanmugam Mahesh P, Gupta Aditi, Sharma Tarun, Bhende Pramod, Muthukumar Siva, Subramaniam R, Kuppuswamy Thayalan, Saxena S K, Dash Ashutosh. Brachytherapy of intra ocular tumors using ‘BARC I-125 Ocu-Prosta seeds’: An Indian experience. Indian Journal of Ophthalmology. 2014 Feb ; 62 (2): 158-162.