Expression of galectin-3 in gastric adenocarcinoma.
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Date
2014-07
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Abstract
Background & objectives: Galectin-3 a member of the galectin family is an endogenous β-galactoside
binding lectin. It has been found to be associated with cell adhesion, recognition, proliferation,
differentiation, immunomodulation, angiogenesis, apoptosis and can be a reliable marker for cancer
aggressiveness. The aim of this study was to verify protein expression in gastric adenocarcinoma tissues
and correlate the results with the clinical aspects in the study population.
Methods: Galectin-3 expression was examined by immunohistochemistry in 57 samples of gastric
adenocarcinomas tissues. Galectin-3 protein expression was observed in the cytoplasm and the nucleus
of examined tissues.
Results: Thirty one (54.4%) samples had strong or moderate staining and 26 (45.6%) tumours had
negative or weak staining. The galectin-3 did not show association with the sex (p=0.347), age (p=0.999),
Lauren’s classification (p=0.731) and TNM stage (p=0.222). Regarding the TNM stage, 66.7 per cent of
stage I tumours had strong or moderate staining; with tumours stage IV this percentage was 33.3 per
cent.
Interpretation & conclusion: Our results suggest that gal-3 is not a reliable biomarker for prognosis of the
gastric adenocarcinoma by immunohistochemistry. Further studies need to be done on a large sample of
tumour tissues in different clinical staging
Description
Keywords
biomarker, galectin-3, gastric adenocarcinoma, immunoexpression, prognosis
Citation
Gomes Thiago Simão, Fujiyama Oshima Celina Tizuko, Forones Nora Manoukian, Oliveira Lima Flávio De, Ribeiro Daniel Araki. Expression of galectin-3 in gastric adenocarcinoma. Indian Journal of Medical Research. 2014 Jul;140 (1): 69-76.