Extramammary Paget's disease: Analysis of 17 Chinese cases.
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Date
2014-03
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Abstract
Background/Objective: Extramammary Paget’s Disease (EMPD) seems to be more
common in Caucasians than Chinese. We report the clinical manifestations, management,
and prognostic characteristics in 17 Chinese patients. Methods: Medical records and
biopsies of 17 patients who had been treated at a large university hospital in China
between March 2005 and January 2012 were reviewed. Results: Of the 17 patients,
14 were men. They had lesions on the scrotum and the penis. Of the three women,
two had vulvar and one had inguinal lesions. All patients underwent Mohs micrographic
surgery (MMS). Three men had metastasis to the inguinal lymph nodes and underwent an
extensive local excision with inguinal lymphadenectomy. Eight patients who had positive
excision margins received additional radiation therapy. The mean follow-up duration was
54 months (4-85 months). One patient had two recurrences. Three had metastasis to the
inguinal lymph node. One had metastasis to the bone and concomitant prostate cancer.
Two patients died of the disease. Conclusion: A striking difference in presentation of
EMPD in Chinese compared with Caucasians is the male predominance and location on
the penis and scrotum. Mohs micrographic surgery followed by radiotherapy is an effective
treatment. Long-term follow-up suggests that the disease has a good prognosis when it
does not metastasise.
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Keywords
Extramammary paget’s disease, mohs micrographic surgery, prognosis
Citation
Qi Yuqing, Hu Jianzhong, Sun Chenwei, Zhang Junyan, Liu Quanzhong. Extramammary Paget's disease: Analysis of 17 Chinese cases. Indian Journal of Dermatology, Venereology and Leprology. 2014 Mar-Apr; 80(2): 129-133.