Acitretin in dermatology.
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Date
2013-11
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Abstract
Acitretin, a synthetic retinoid has gradually replaced etretinate in today’s dermatologic
practice because of its more favorable pharmacokinetics. Acitretin over the past 20 years has
proven useful in a number of diffi cult-to-treat hyperkeratotic and infl ammatory dermatoses
and nonmelanoma skin cancers. It is effective both as monotherapy and in combination with
other drugs for hyperkeratotic disorders. It is considered to be an established second line
treatment for psoriasis and exerts its effect mainly due to its antikeratinizing, antiinfl ammatory,
and antiproliferative effect. Its antineoplastic properties make it a useful agent for cancer
prophylaxis. Evidence-based effi cacy, side-effect profi le, and approach to the use of acitretin
would be discussed in this review. In addition to its approved uses, the various off label uses
will also be highlighted in this section. Since its use is limited by its teratogenic potential and
other adverse effects, including mucocutaneous effects and hepatotoxicity, this review would
summarize the contraindications and precautions to be exercised before prescribing acitretin.
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Keywords
Acitretin, chemoprevention, psoriasis
Citation
Sarkar Rashmi, Chugh Shikha, Garg Vijay K. Acitretin in dermatology. Indian Journal of Dermatology, Venereology and Leprology. 2013 Nov-Dec; 79(6): 759-771.