New insights in the pathogenesis of type 1 and type 2 lepra reaction.
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Date
2013-11
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Abstract
In the current scenario of leprosy elimination, lepra reactions (LRs) remain a major persistent
problem. Type 1 LR (T1LR) and type 2 LR (T2LR) are the major causes of nerve damage and
permanent disabilities. The immunopathogenesis of LR have recently become an important
fi eld of research, since it may provide the relevant targets for the early detection and control
of these episodes. Presently, there are no uniformly acceptable laboratory markers for LR.
Genetic and serum markers in human host may predict susceptibility to reactions as well as
progression of nerve damage in leprosy. Therefore, a deeper understanding of the molecular
mechanisms involved in LR may provide a rational strategy for early diagnosis and prevention
of the catastrophic consequences of LR.
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Keywords
Biomarkers, erythema nodosum leprosum, leprosy, type 1 lepra reaction, type 2 lepra reaction, toll like receptor, nerve damage
Citation
Pandhi Deepika, Chhabra Namrata. New insights in the pathogenesis of type 1 and type 2 lepra reaction. Indian Journal of Dermatology, Venereology and Leprology. 2013 Nov-Dec; 79(6): 739-749.