Sodium fluoride and casein phosphopeptide-amorphous calcium phosphate cream plus sodium fluoride efficacy in preventing enamel erosion in a simulated oral environment study model.
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Date
2014-07
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Abstract
Aim: The aim of this study was to evaluate the effectiveness of dentifrices containing high
concentrations of sodium fluoride (NaF) and casein phosphopeptide‑amorphous calcium
phosphate cream plus fluoride (CPP‑ACPF) in prevention of the erosion in a simulated oral
environment study model.
Subjects and Methods: Fifteen flat human enamel specimens were polished and half of the
surfaces were protected with adhesive tape. Initial Knoop microhardness (KHN) and surface
roughness (SR) were measured, and specimens were assigned to four groups: Control (placebo
toothpaste – G1); CPP‑ACPF (G2), NaF 1450 ppm (G3), and NaF 5000 ppm (G4). Enamel surfaces
were brushed 3 times daily in association with demineralization‑remineralization cycles (5s in
cola drink + 5s in artificial saliva/10 cycles/twice daily) and the specimens were maintained in
a salivary flow simulator apparatus. After 14 days, KHN and SR were measured again, and the
enamel surfaces were analyzed by scanning electronic microscopy (SEM).
Statistical Analysis Used: Data were analyzed using the two‑way ANOVA and Student–Newman–
Keuls multiple range test (α =0.05).
Results: All the tested groups presented a decrease in KHN after 14 days (P < 0.05). There was
no statistical significance among materials tested. Significant increase in SR was observed for all
groups. SEM analysis showed morphological alterations with honeycomb structures in enamel
surfaces in the four experimental groups.
Conclusions: It was concluded that tooth brushing with dentifrices with high concentration of
NaF and CPP‑ACPF cream was not able to prevent enamel erosion in simulated oral environment.
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Keywords
Erosion, caseins, dental enamel, fluorides, toothpastes
Citation
Amaral Cristiane Mariote, Miranda Maria Elisa da Silva N G, Correa Danielly S, Silva Eduardo M. Sodium fluoride and casein phosphopeptide-amorphous calcium phosphate cream plus sodium fluoride efficacy in preventing enamel erosion in a simulated oral environment study model. Indian Journal of Dental Research. 2014 Jul-Aug; 25(4): 464-469.