Comparative study of various grading systems in oral squamous cell carcinoma and their value in predicting lymph node metastasis.
Loading...
Date
2014-05
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Background: Regional lymph node (LN) metastasis is the single most prognostic factor for
oral squamous cell carcinoma (OSCC). An analysis of the prognostic factors is important for
predicting prognosis and reducing the mortality in these patients.
Objectives: (1) To compare the value of various grading systems in predicting LN metastasis.
(2) To evaluate histopathological parameters, which could help in predicting LN metastasis.
Materials and Methods: A total of 20 excisional biopsies of OSCCs, were graded according to the
four grading systems that is, Broder’s, Jakobsson's, Anneroth and Hansen’s, and Brynes. We also
evaluated various histopathological parameters, which could help in predicting LN metastasis.
Results: Grading at the invasive front was most prognostic of LN metastasis. Tumors with total
malignancy score ≥8 showed higher incidence of metastases.
Conclusion: The histopathological parameters that could help in predicting lymph node
metastases (LNM) are keratinization, nuclear pleomorphism (NP), and the pattern of
invasion (POI) when assessed at the invasive front. When the whole tumor was considered,
histopathological parameters like NP and POI were significant in predicting LNM.
Description
Keywords
Malignancy grading system, metastases, oral squamous cell carcinoma, prognostic parameters
Citation
Jamadar Saleha, Narayan T V, Shreedhar Balasundari, Mohanty Leeky, Shenoy Sadhana. Comparative study of various grading systems in oral squamous cell carcinoma and their value in predicting lymph node metastasis. Indian Journal of Dental Research. 2014 May-Jun; 25(3): 357-363.