Central odontogenic fibroma: Report of case with immunohistochemical study.
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Date
2013-11
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Abstract
Objectives: To report a case of central odontogenic fibroma (COF) with immunohistochemical
study.
Clinical Presentation: We describe a case of epithelium‑rich type of COF in the posterior
region of the mandible of a 39‑year‑old woman. Immunohistochemical examination showed
the odontogenic epithelium to be positive for high‑molecular‑weight cytokeratins, vimentin
and CD99, and negative for CAM5.2. The stroma contained some myofibroblasts and many
fibroblast‑like cells positive for CD99.
Conclusion: Our immunohistochemical findings, and especially the positive expression of
vimentin from the epithelial cells of COF suggests that these cells are primordial. Last but
not least, the presence of a relative small number of myofibroblasts in the stroma justifies the
non‑aggressive behavior of the neoplasm and supports that a part of stromal collagen of COF
is produced by these cells.
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Keywords
Central odontogenic fibroma, CD 99, cytokeratins, immuno‑histochemistry, myofibroblasts, odontogenic tumors, vimentin
Citation
Iordanidis Savas, Poulopoulos Athanasios, Epivatianos Apostolos, Zouloumis Lambros. Central odontogenic fibroma: Report of case with immunohistochemical study. Indian Journal of Dental Research. 2013 Nov-Dec; 24(6): 753-755.