The wound healing property of ethanolic extract of Michelia champaca flowers in diabetic rats.
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Date
2014-11
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Abstract
Background: The plant Michelia champaca (MC) is widely used in the treatment
of inflammation, constipation, dysmenorrhea, ulcers, wounds, fever, and cough. The
aim was to evaluate the wound healing property of ethanolic extract of MC flowers
in streptozotocin-induced diabetes in rats.
Methods: Wound healing activity was assessed by incision and excision wound
models. Five groups of n=6 rats and n=14 rats were used for incision and excision
wound models, respectively. Group I rats, non-diabetic control and Group II rats
diabetic control, received 1 ml of 0.5% caboxymethylcellolose, which was used
to prepare a suspension of ethanolic extracts of MC. Group III, IV and V rats
were given MC extract the suspension of 100 mg/kg, 200 mg/kg and 300 mg/kg
respectively. Parameters observed were breaking strength of incision wound and
wound contraction, epithelialization, hydroxyproline content of excision wound
respectively. Results were analyzed using one-way analysis of variance, followed
by Tukey’s post-hoc test.
Results: Breaking strength, rate of wound contraction and hydroxyproline content
were significantly increased, and the period of epithelialization was significantly
reduced in Group IV and V rats respectively.
Conclusion: Oral administration of ethanolic extract of MC promotes wound healing
in diabetic rats. Hence, further study in humans is suggested.
Description
Keywords
Incision wound, Excision wound, Hydroxyproline and diabetic rats
Citation
Gowda Amoolya, Shanbhag Venkatesh, Bangalore Eesha Rao, Shenoy Smita, Prabhu Krishnananda, Narayanareddy Mukunda, Shanbhag Tara. The wound healing property of ethanolic extract of Michelia champaca flowers in diabetic rats. International Journal of Basic & Clinical Pharmacology. 2014 Nov-Dec; 3(6): 1036-1042.