Evaluation of analgesic activity of Emblica officinalis in albino rats.
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Date
2014-03
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Abstract
Background: Amla is one of the most often used herbs in indigenous medicine,
whose all parts including fruit, seed, leaves, root, bark, and fl owers are used in
various Ayurvedic/Unani medicines. However, studies to establish analgesic potential
of amla were limited, so the purpose of the present study was to evaluate analgesic
activity of amla, if it possesses any.
Methods: Albino rats were divided randomly in three groups of six rats each. Group 1
(control) received distilled water orally, Group 2 (test) received Emblica offi cinalis
extract in dose of 600 mg/kg orally and Group 3 (standard) received Pentazocine in
dose 10 mg/kg intraperitoneally.
Results: Emblica offi cinalis extract did not produced statistically signifi cant (p>0.05)
analgesia when compared with the control group in hot plate latency, but produced a
statistically signifi cant reduction in 6% NaCl induced abdominal writhing (p<0.05).
Conclusions: Since the plant extract signifi cantly reduced the number of writhes in
abdominal writhing model, but do not increase hot plate latency, the commercially
available crude extract of Emblica offi cinalis exhibit analgesic activity involving
peripheral mechanisms.
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Keywords
Emblica officinalis, Amla, Anti-nociceptive, Pain, Analgesic, Hot plate method
Citation
Goel Bhomik, Pathak Nishant, Nim Dwividendra Kumar, Singh Sanjay Kumar, Dixit Rakesh Kumar, Chaurasia Rakesh. Evaluation of analgesic activity of Emblica officinalis in albino rats. International Journal of Basic & Clinical Pharmacology. 2014 Mar-Apr; 3(2): 365-368.