Effect of gamma linolenic acid pretreatment on diabetic neuropathy in rats.
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Date
2013-05
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Abstract
Background: The present study was planned to evaluate the preventive effects of gamma linolenic acid (GLA) on STZ induced diabetic neuropathy
Methods: Streptozotocin (STZ) induced diabetic neuropathy in rats was monitored by measuring blood sugar levels, body weight, motor nerve conduction velocity (MNCV) and nociception. Forty rats were divided into 4 groups of 10 each. Group 1: control (vehicle), Group 2: STZ (50 mg/kg, i.v., single injection), Group 3: Gamma linolenic acid (50 mg/ kg, p.o., daily + STZ), Group 4: STZ + Insulin (4 units/kg, s.c., bid). Similar protocol was used for other parameters also.
Results: Gamma linolenic acid pretreatment failed to reduce blood sugar levels in diabetic rats but prevented deterioration of motor nerve conduction velocity as compared to STZ diabetic rats. A significant weight gain was observed in STZ diabetic rats pretreated with GLA as compared to rats received STZ alone. Hyperalgesia induced by STZ was antagonized by GLA
Conclusions: Thus gamma linolenic acid prevents the development of neuropathic changes induced by STZ in rats.
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Keywords
Diabetic neuropathy, Gamma linolenic acid, STZ, MNCV, Hyperalgesia
Citation
Nishikant, Singh Janardhan, Sood Sushma, Vijayshanker. Effect of gamma linolenic acid pretreatment on diabetic neuropathy in rats. International Journal of Basic & Clinical Pharmacology. 2013 May-Jun; 2(3): 320-325.