Coronary artery bypass grafting in a patient with protein S deficiency: Perioperative implications.
Loading...
Date
2013-07
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Protein S (PS) along with activated protein C plays an important role in the down-regulation of in vivo
thrombin generation. Its defi ciency can cause abnormal and inappropriate clot formation within the circulation
necessitating chronic anticoagulation therapy. The risk of developing thrombotic complications is heightened in
the perioperative period in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). Heparin
resistance is very rare in these patients, especially when antithrombin levels are near normal. Management
of CPB in this scenario is quite challenging. We report the perioperative management, particularly the
CPB management, of a patient with type I PS defi ciency and incidentally detected heparin resistance, who
underwent coronary artery bypass grafting with CPB.
Description
Keywords
Cardiopulmonary bypass, Coronary artery bypass grafting, Heparin resistance, Hypercoagulable states, Protein S deficiency
Citation
Balan Baskaran, Chengode Suresh, Sabti Hilal Al, Rao Ram Narayan. Coronary artery bypass grafting in a patient with protein S deficiency: Perioperative implications. Annals of Cardiac Anaesthesia. 2014 Jul; 17(3): 232-236.