Identification of predictive marker of prerenal damage in pregnant women with Preeclampsia and women at high risk- A Prospective study conducted in Riyadh,Saudi Arabia.
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Date
2014-03
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Abstract
Background: Preeclampsia is characterized by development of high blood pressure and proteinuria. It affects 5–8% of all pregnancies and is a major contributor to maternal and fetal morbidity and mortality. There is no single test that fulfils all the criteria for a good predictor of preeclampsia and associated renal damage.
Aims & Objectives: To evaluate the role of serum and urine biochemical parameters as early predictors of preeclampsia. To investigate the role of BUN: Creatinine ratio in diagnosing preeclampsia and evaluating prognosis of the disease.
Material and Methods: In the present prospective study, one hundred and twenty pregnant women divided into three groups: normotensive (control), women at high risk and with preeclampsia were included. Analyses of different biochemical parameters including BUN: Creatinine were carried out.
Results: There was significant difference in the mean value of serum uric acid, blood urea nitrogen, creatinine, urinary protein and BUN: Creatinine ratio in preeclampsia group compared to control group (p < 0.001). There was significant difference (p < 0.05) in serum uric acid between control and preeclampsia group. However, there was no significant change in haematocrit, serum creatinine and urine protein between control and high risk group.
Conclusion: BUN: Creatinine ratio in pregnant women with preeclampsia and also in high risk group was significantly increased (t = 15.55, p < 0.001 and t = 8.66, p < 0.001 respectively) in comparison to the control group. This index could be useful in evaluating the severity of preeclampsia and could be used as a predictor in prognosis of preeclampsia and subsequent early renal disease.
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Keywords
Blood Urea Nitrogen, Creatinine Ratio (BUN:Cr), Maternal Mortality, Preeclampsia, Renal Dysfunction
Citation
Jameil Noura Al, Tabassum Hajera, Mayouf Huda Al, Otay Latifa Al, Shenefy Amal Ali Al, Khan Farah Aziz. Identification of predictive marker of prerenal damage in pregnant women with Preeclampsia and women at high risk- A Prospective study conducted in Riyadh,Saudi Arabia. International Journal of Medical Science and Public Health. 2014 ; 3(2): 186-190.