Roles of PI3K/AKT/PTEN pathway in the pathogenesis of parkinson’s disease and the neuropsychiatric symptoms.
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Date
2014-01
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Abstract
Parkinson's disease is a neurodegenerative disorder associated with loss of
dopaminergic neurons in substantianigra caused by severe neuro-degeneration, which is
the second most common neurodegenerative disorder after Alzheimer’s
disease.Parkinson's disease has a high prevalence of psychiatric comorbidity including
depression. The neuropsychiatric symptoms are common in Parkinson's disease and
may precede onset of motor symptoms. Increasing interest is often addressed to the
selective targeting of some of metabotropic glutamate receptors that inhibit the
transmitter release at synapses in the basal ganglia. The metabotropic glutamate
receptors may be coupled to the phosphatidylinositol-3-kinase (PI3K), AKT, and PTEN
pathways, whichplay a central role in cell survival. A better understanding of the
molecular connections in the PI3K pathways could uncover new targets for drug
development in Parkinson's disease.
Description
Keywords
Parkinson’s disease, depression, mGlu receptors, PI3K, AKT, PTEN
Citation
Kitagishi Yasuko, Wada Yoko, Matsuda Satoru. Roles of PI3K/AKT/PTEN pathway in the pathogenesis of parkinson’s disease and the neuropsychiatric symptoms. International Neuropsychiatric Disease Journal. 2014 Jan-Feb 2(1): 1-12.