Healing effect of terminalia chebula fruit extract on trinitrobenzene sulfonic acid induced colitis in rat.
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Date
2013-07
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Abstract
The present study aims to evaluate healing effect of 50%
ethanolic extract of Terminalia chebula fruit pulp (TCE) on trinitrobenzene
sulfonic acid (TNBS, intra-colonic route) induced colitis in rats. TCE (600
mg/kg, oral) was studied in TNBS-induced colitis for its effects on fecal
output, food and water intake and body weight changes, histology,
antibacterial activity and levels of free radicals (nitric oxide and lipid
peroxidation), antioxidants (superoxide dismutase; catalase and reduced
glutathione) and acute inflammatory marker (myeloperoxidase) in colonic
tissue. TNBS administration increased colonic mucosal damage and
inflammation (macroscopic and microscopic) and stool output but decreased
body weight which was reversed by TCE treatment. TCE showed significant
antibacterial activity and enhanced the antioxidants but decreased free
radicals and myeloperoxidase activities affected in TNBS colitis. Thus,
Terminalia chebula dried fruit pulp extract healed colitis by promoting
antioxidant status and decreasing intestinal bacterial load, free radicals and
myeloperoxidase responsible for tissue damage and delayed healing.
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Keywords
terminalia chebula, colitis, free radicals, antioxidants, myeloperoxidase, antimicrobial activity
Citation
Gautam Manish K, Ghatule Rohit R, Singh Amit, Kumar Mohan, Goel Raj K. Healing effect of terminalia chebula fruit extract on trinitrobenzene sulfonic acid induced colitis in rat. Indian Journal of Physiology and Pharmacology. 2013 Jul-Sept; 57(3): 325-336.