Impact of different starting doses of atorvastatin on reaching target low density lipoprotein cholesterol levels and health related quality of life in dyslipidemic patients.
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Date
2013-07
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Abstract
Objectives : 1. To compare the percentage of patients that
reach target LDL-C goals with 10 mg Vs. 20 mg of atorvastatin as a starting
dose. 2. To compare Health Related Quality of Life (HRQOL) in patients on
10 mg Vs. 20 mg of atorvastatin.
Methods : A prospective, double blind, parallel groups, unicentric study of
patients of dyslipidemia, randomized to receive atorvastatin 10 mg (n=75)
or atorvastatin 20 mg (n=75) once daily for 12 weeks. Safety reporting of
incidence of adverse events was done.
Results : Significantly more number of patients (P<0.05) reached target
LDL-C levels at the end of 12 weeks in the 20 mg group (77.27% in the
high risk group, 100% in moderately high risk group and 100% in the
moderate risk group) when compared to 10 mg group (32% in the high risk
group, 75% in moderately high risk group and 83.33% in the moderate risk
group). Increase in HRQOL at the end of 12 weeks was also significantly
greater (P<0.001) in 20 mg group (27.89%) vs. 10 mg group (19.26%).
Conclusions : Selecting the starting dose of atorvastatin according to the
patients risk category (by using the Framingham’s algorithm for calculating
cardiovascular risk) and the percentage reduction in LDL required, will
result in greater success in achieving LDL goals and better quality of life.
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Keywords
atorvastatin, dyslipidemia, LDL-C goal, quality of life
Citation
Ghia C J, Panda S K, Khobragade L R, Jha R K. Impact of different starting doses of atorvastatin on reaching target low density lipoprotein cholesterol levels and health related quality of life in dyslipidemic patients. Indian Journal of Physiology and Pharmacology. 2013 Jul-Sept; 57(3): 293-307.