Protective effect of -tocopherol against hematotoxicity, hepatotoxicity and nephrotoxicity induced by nickel sulfate in male albino rats.
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Date
2013-07
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Abstract
Among the chemical hazards, heavy metal like nickel (Ni) is
considered to be a serious one. It induces severe liver and kidney damage
by altering several marker enzymes and ascorbate-cholesterol metabolism.
The objective of the study was to investigate the possible protective role
of α-tocopherol on NiSO4 (Ni II) exposed alteration of hematological
parameters, markers of liver and kidney functions, hepatic and renal antioxidant
defense system in male albino rats. We have studied the effects of α-tocopherol
supplementation on nickel sulfate induced alteration of body weight,
hematology, liver and kidney toxicity markers (SGOT, SGPT, total protein,
urea, creatinine) and hepatic and renal antioxidant defense system of male
albino rats. Nickel toxicity results in decreased body weight gain and relative
liver and kidney weight. Nickel treatment also resulted in alteration of
hematological parameters along with increased liver and kidney toxicity
markers. Nickel sulfate administration significantly increased the level of
lipid peroxides and decreased antioxidant enzyme activities in hepatic and
renal tissue. Simultaneous treatment with á-tocopherol exhibited a possible
protective role on the toxic effect of nickel on body and organ weights,
hematological parameters, SGPT activity and improved tissue antioxidant
defense system. α-tocopherol, may partially prevent nickel induced alteration of
hematological and biochemical parameters as well as have amelioratic effects
on nickel induced alteration of antioxidant status of liver and kidney.
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Keywords
α-tocopherol, antioxidant defense, hematology, nickel sulfate, SGOT/SGPT
Citation
Tikare Swati N, Yendigeri Saeed, Gupta Amrita Das, Dhundasi Salim A, Das Kusal K. Protective effect of -tocopherol against hematotoxicity, hepatotoxicity and nephrotoxicity induced by nickel sulfate in male albino rats. Indian Journal of Physiology and Pharmacology. 2013 Jul-Sept; 57(3): 280-292.