Region-wise gray matter volume alterations in brain of adolescents with attention deficit hyperactive disorder : A voxel based morphometric analysis.
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Date
2013-07
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Abstract
Attention Deficit Hyperactive Disorder (ADHD) is a behavioral
neuropsychiatric disorder affecting an estimated 5% of school-age children
worldwide with symptoms persisting into adulthood in 80% of cases.
Presently clinical diagnosis and treatment of ADHD relies on behavioral
disturbances than on detecting underlying defective brain regions.
Therapeutic outcome in treatment of ADHD may be more positive if defective
brain region in clinically diagnosed ADHD is detected by voxel based
morphometric (VBM) analysis that measures voxel-wise global and regional
focal volume differences in structural magnetic resonance images (sMRI)
of brain. This study was designed to detect any region-specific gray matter
(GM) volume defects in sMRI of ADHD adolescents by VBM analysis. Thirty
sMRI datasets matched for sex, handedness of adolescents aged between
11.66 and 20.47 years (mean age 16.27±2.48 years) obtained from
NeuroImage webpage, were selected (Control n=15; ADHD combined type
n=15). These sMRI were analyzed by VBM technique and compared using
statistical parametric mapping (SPM). Significant regional GM volume deficits
(P<0.05) was specifically identified in left cuneus and middle occipital gyrus
in ADHD, after voxel-wise false discovery rate correction over the whole
brain compared to matched controls. Deficit of GM volume in occipital
cortex detected by VBM analysis in ADHD children, suggests defects of
visual processing affecting attention mechanisms.
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Keywords
ADHD, occipital gyrus, sMRI, VBM analysis
Citation
Ramesh M G, Rai Kiranmai S. Region-wise gray matter volume alterations in brain of adolescents with attention deficit hyperactive disorder : A voxel based morphometric analysis. Indian Journal of Physiology and Pharmacology. 2013 Jul-Sept; 57(3): 270-279.