An in vitro analysis of antiproliferative and antimicrobial activities of solvent fractions of Taraxacum officinale (Dandelion) leaf.
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Date
2014-03
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Abstract
The persistent upsurge in multidrug resistance of common pathogens and global increase in the incidence of noninfectious
diseases such as cancers and diabetes has led to an urgent need for the discovery of novel and
affordable pharmaceuticals. Taraxacum officinale commonly called dandelion has been used in traditional
medicine for the treatment of various conditions. Although the antimicrobial and antiproliferative properties of
various crude extracts of T. officinale have been reported, there is little report on the antimicrobial and
antiproliferative activities of its solvent fractions. In this study, various solvent fractions from the crude
methanolic extract of T. officinale leaves were examined for their antiproliferative and antimicrobial activities
with the aim of providing a baseline data for the discovery of the antiproliferative and antimicrobial
phytocompounds in T. officinale leaves. Whereas, methylene chloride fraction showed the highest antiproferative
activity, inhibiting 97 % proliferation of SGT oral cancer cells the butanol fraction showed the highest
antimicrobial activity in both disc diffusion and broth dilution assays. Therefore the methylene chloride and the
butanolic fractions could respectively act as leads for the discovery of important anticancer and antimicrobial
phytocompounds from T. officinale.
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Keywords
Antiproliferative, antimicrobial, solvent fractions, Taraxacum officinale leaf extract
Citation
Tettey C O, Ocloo A, Nagajyothi P C N, Lee K D. An in vitro analysis of antiproliferative and antimicrobial activities of solvent fractions of Taraxacum officinale (Dandelion) leaf. Journal of Applied Pharmaceutical Science. 2014 Mar; 4(3): 41-45.