Bioadhesive buccal gels impregnated with fluconazole: formulation, in vitro and ex vivo characterization.
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Date
2014-03
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Abstract
This study describes the formulation of bioadhesive buccal gels for fluconazole delivery via buccal mucosa. In
the present study the polymer with well-defined mucoadhesive properties like Carbopol 934 was used. Carbopol-
Poloxamer gels of 1% fluconazole was formulated with various absorption enhancers like polyethylene glycol,
propylene glycol, glycerol, phosphatidylcholine, mannitol and sodium lauryl sulphate by cold method. The gels
were characterised for gelation temperature, bioadhesive force, pH, viscosity, drug release profile, ex vivo
permeation across goat buccal mucosa and stability profile. The percent drug permeated through the buccal
mucosa was in the range of 62-76%. Polyethylene glycol and propylene glycol were found to be better absorption
enhancers as compared to others and followed zero order release kinetics.
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Keywords
Mucoadhesive, bioadhesion, fluconazole, oral candidiasis, residence time
Citation
Suresh Preeti K, Manhar Sanju. Bioadhesive buccal gels impregnated with fluconazole: formulation, in vitro and ex vivo characterization. Journal of Applied Pharmaceutical Science. 2014 Mar; 4(3): 15-19.