Effect of some antioxidants on the prostate of adult and aged albino rats: a histological and immunohistochemical study.
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Date
2014-02
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Abstract
Effect of some antioxidants on the prostate of adult and aged albino rats. Twenty-five adult and twenty-five aged
male albino rats were divided into four groups: group I (control group) group II (zinc sulphate treated group),
group III (vitamin E) & group IV (vitamin C) zinc administered in doses of 0.2673 mg for adult rat and 0.693 mg
for aged rat, vitamin E administered in doses of 0.973 mg for adult rat and 2.52 mg for aged rat, vitamin C
administered in doses of 1.215mg for adult rat and 3.15 mg for aged rat. The prostate glands were processed and
stained by H&E, Masson trichrome & immunoreaction of androgen receptor for light microscopic examinations.
Morphometric analysis for collagen fibers and immunoreaction area percent was performed and statically
analyzed. Zinc showed improvements, in which decrease in number of mucosal fold and increase in
immunoreactions of nuclear androgen receptor in ventral lobe also, Decrease fibrosis and increase in
immunoreactions of nuclear androgen receptor in dorsolateral lobe. vitamin E showed improvements, in which
decrease in number of mucosal fold, decrease size of acini, decrease of epithelial heights and increase in
immunoreactions of nuclear androgen receptor in ventral lobe also, decrease of epithelial heights, decrease
fibrosis and increase in immunoreactions of nuclear androgen receptor in dorsolateral lobe. vitamin C there were
improvements, in which decrease in number of mucosal fold, dilatation of acini and slightly increase in
immunoreactions of nuclear androgen receptor in ventral lobe also, rarified collagenous fibers and increase in
immunoreactions of nuclear androgen receptor in dorsolateral lobe. It also ameliorated blood vessels congestion.
Zinc, vitamin E and vitamin C exerted no harmful effects on adult prostate but ameliorated effects against aged
prostate.
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Keywords
Aging, prostate, zinc, vitamin E, vitamin C, prostatic hypertrophy, Rat
Citation
Gabry Mohamed Sayed, Kader Dina Helmy Abdel, Moustafa Maiada, Elenany Asmaa Abdel Hamed. Effect of some antioxidants on the prostate of adult and aged albino rats: a histological and immunohistochemical study. Journal of Applied Pharmaceutical Science. 2014 Feb; 4(2): 17-26.