Extraction and characterization of microcrystalline cellulose obtained from the back of the fruit of Lageriana siceraria (water gourd).
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Date
2014-01
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Abstract
The work was aimed to investigate the suitability of acid modified alpha cellulose obtained from the back of the
fruit of Lageriana siceraria (water gourd) in production of pharmaceuticals, particularly solid dosage forms.
Cellulose is the commonest Filler/Binder or disintegrant used in tablet formulation. Cellulose was extracted from
the fruit of Lageriana siceraria and subjected to modification by controlled acid micronisation to produce
microcrystalline cellulose (LS-MCC) using 2.5N hydrochloric acid and Avicel pH 101 was used as the basis for
comparison. The powder and flow properties of the microcrystalline cellulose was investigated and the result of
both the LS-MCC and Avicel pH 101compared. Microcrystalline cellulose (LS-MCC) displayed superior
swelling and hydration capacities as compared to Avicel PH101 but lesser flow properties in view of its higher
angle of repose, Carr’s and Hausner’s index.
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Keywords
Lageriana siceraria, microcrystalline cellulose, acid micronisation, Avicel pH 101
Citation
Achor M, Oyeniyi Y J, Yahaya A. Extraction and characterization of microcrystalline cellulose obtained from the back of the fruit of Lageriana siceraria (water gourd). Journal of Applied Pharmaceutical Science. 2014 Jan; 4(1): 57-60.