Efficacy of 5-(2-aroyl)aryloxy methyl-2-phenyl-1,3,4-oxadiazoles as antibacterial and antifungal agents.
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Date
2013-11
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Abstract
Research and development of potent and effective antimicrobial agents represent one of the most important
advances in therapeutics; the main aim of these efforts is not only control the serious infections, but also
prevention and treatment of some infectious complications of other therapeutic modalities. A series of 5-(2-
aroyl)aryloxy methyl-2-phenyl-1,3,4-oxadiazoles were screened for their antibacterial and antifungal activities.
Anti-bacterial activity against B. cereus, S. aureus, B. subtilis, S. aureus (MRSA), E. aerogenes, M. luteus, K.
pneumonia, P. aeruginosa, S. typhimurium, E. coli, paratyphi-B, P. vulgaris bacterial strains and anti-fungal
activity against C. albicans, A.niger, F.solani, A.flavus, B.cinerea, C.krusei, M. pachydermatis, C.parapsilosis,
F.moniliforme, C.gloeosporioides fungal strains were carried out. The bioassays indicated that most of the
synthesized compounds showed potential antibacterial and anti-fungal activity.
Description
Keywords
1, 3, 4-oxadiazoles, Antibacterial assay, Antifungal activity
Citation
Begum A Bushra, Khanum Noor Fatima, Naveen P, Ranganatha V Lakshmi, Asha M S, Khanum Shaukath Ara. Efficacy of 5-(2-aroyl)aryloxy methyl-2-phenyl-1,3,4-oxadiazoles as antibacterial and antifungal agents. Journal of Applied Pharmaceutical Science. 2013 Nov; 3(11): 105-109.