Formulation and Optimization of Chronotherapeutic Drug Delivery from Carvedilol Sulphate Compression Coated Tablets by using Design of Experiment Approach.
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Date
2013-10
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Abstract
The aim of this present work was to develop and optimize compression coated tablet of carvedilol sulphate for
chronotherapeutic application by response surface methodology based on 32 factorial designs. Compression
coated tablet containing carvedilol phosphate in the core was formulated with an outer coat by eudragit L 100 and
ethyl cellulose. The percentage weight ratio of ethyl cellulose to eudragit L 100 and coating level were selected
as critical process parameters (CPPs), whereas critical quality attributes (CQAs) were lag time and cumulative
percentage drug release at 8 hr in current study. For optimization, the effects of critical process parameters upon
the critical quality attributes were modelled using the polynomial equations involving critical process parameters
and their interactions for various critical quality attributes. A numerical optimization technique was adopted to
achieve optimized formulation which was also used as the check point.The observed responses were closed well
with the predicted values. The formulation exhibited pulsed release profile after a programmed lag time and thus
suitable for chronotherapeutic delivery. The study demonstrated a successful optimized formulation followed by
evaluation of compression coated tablet of carvedilol sulphate for chronotherapeutic drug delivery.
Description
Keywords
Chronotherapeutic, Compression coated tablet, Response surface methodology, critical process parameters, critical quality attributes
Citation
Aggarwal Vaishali, Kumar Ratendra, Sharma Rajiv, Singh Yogendra, Teotia Uday Veer Singh. Formulation and Optimization of Chronotherapeutic Drug Delivery from Carvedilol Sulphate Compression Coated Tablets by using Design of Experiment Approach. Journal of Applied Pharmaceutical Science. 2013 Oct; 3(10): 141-146.