Evaluation of the hepatoprotective effect of the methanol extract of the root of Uvaria afzelii (Annonaceae).
Loading...
Date
2013-10
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The claimed hepatoprotective effect of the root of Uvaria afzelii Sc. Elliot (Annonaceae) was investigated using
the Carbon tetrachloride induced hepatotoxicity in albino rats as a template. The methanolic extract of U. afzelii
co-comittantly administered with carbon tetrachloride at doses of 125, 250 and 500mg/kg was found to
significantly (p<0.05) reduce the levels of alanine aminotransfarase (AST), aspartate transaminase (AST),
alkaline phosphatase (ALP), total and un-conjugated bilirubin, while levels of total protein and albumin were
significantly increased in a non dose-dependent pattern, compared to animals treated with carbon tetrachloride
alone, where the activity of ALT, AST, ALT, total and un-conjugated bilirubin increased and that of total protein
and serum albumin decreased. Histopathological examinations supported the biochemical results. This study
conclusively provides scientific validation for the use of extract of the root of U. afzelii in ethnomedicine to
manage jaundice and liver injury.
Description
Keywords
Hepatoprotective, Uvaria afzelii, Annonaceae, Carbontetrachloride
Citation
OFEIMUN Josephine Omose, EZE Gerald Ikechi, OKIRIKA Ogochukwu Marvin, UANSEOJE Sylvester O. Evaluation of the hepatoprotective effect of the methanol extract of the root of Uvaria afzelii (Annonaceae). Journal of Applied Pharmaceutical Science. 2013 Oct; 3(10): 125-129.