The potential role of Red Tilapia (Oreochromis niloticus) scales: allergic reaction test in mice.
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Date
2013-10
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Abstract
Red tilapia (Oreochromis niloticus) is one of aquaculture’s most adaptive species. It is abundantly found in the
wild and known to be cultured in several parts of the world. It is mainly a freshwater fish, inhabiting shallow
streams, ponds, rivers and lakes but less commonly found living in brackish water. The concept of ‘waste to
wealth’ has been applied widely as an alternative to waste reduction and environmental conservation. Based on
these perspectives, the present study was conducted to assess possible medicinal and pharmaceutical values of the
tilapia. The mice model of delayed-contact hypersensitivity test, the mice ear swelling test (MEST), was chosen
for this study due to its ability to predict contact sensitization with less cost and time consumed. Four female
BALB/c mice were tested in each group which included controls. Three different doses of scales powder at 500,
1000, and 2000 mg/kg in an acetone and olive oil (AOO) solution were formulated and applied to shaved dorsal
trunk of the mice at induction phase, and to both sides of each ear of the mice at elicitation phase. From the
observations made throughout the study period, neither erythema nor oedema was formed on the skin of mice
treated with scales powder in AOO solution. Mice ear thickness increase showed percentage ear swelling of no
more than 20%. Thus, the finding of this study showed that the scales of red tilapia fish did not induce allergic
sensitization and could have an application in medicinal and pharmaceutical industries.
Description
Keywords
Red Tilapia, Scales, Mice, Olive oil, Dermal reactions, Ear swelling test, Allergic sensitization, Pharmaceutical industries
Citation
Rahman Suzanah Abdul, Zambry Husna, Basha Sadak, Kamarzaman Saheera, Chowdhury Ahmed Jalal Khan. The potential role of Red Tilapia (Oreochromis niloticus) scales: allergic reaction test in mice. Journal of Applied Pharmaceutical Science. 2013 Oct; 3(10): 45-50.