Prolonged-release lipid microparticles prepared with decyl oleate and hydrogenated castor oil of ibuprofen.
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Date
2013-10
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Abstract
Ibuprofen is one of the most important non-steroidal anti-inflammatory drugs used in the treatment of
inflammatory diseases. In its pure state, ibuprofen presents poor physical and mechanical characteristics and its
use in solid dosage forms needs the addition of excipients that improve these properties. The selection of the best
excipients and the most suitable pharmaceutical dosage form to carry ibuprofen is very important for the
industrial success of this drug. Given these factors, lipid microparticles of ibuprofen with decyl oleate and
hydrogenated castor oil were prepared. This formulation was intended to improve the content of ibuprofen in
preparation and to sustain the release of this drug. Lipid microparticles were submitted to determination of
ibuprofen content using UV-VIS spectrophotometry and, gelatin capsules filled with lipid microparticles and
tablets prepared with these microparticles were submitted to dissolution tests in order to study the influence of the
prepared system in the release profiles of ibuprofen. The improvement of the content of ibuprofen and prolonged
release of this drug was achieved with the lipid microparticles prepared with this mixture of excipients.
Description
Keywords
Ibuprofen, Lipid microparticles, Decyl oleate, Hydrogenated castor oil
Citation
Vieira Felipe Cardoso Rodrigues, Amaral Maria Helena dos Anjos Rodrigues, Lobão Paulo Alexandre Lourenço. Prolonged-release lipid microparticles prepared with decyl oleate and hydrogenated castor oil of ibuprofen. Journal of Applied Pharmaceutical Science. 2013 Oct; 3(10): 8-10.