In Vitro Bronchorelaxant Effects of Capparis Spinosa Aqueous Extracts on Rat Trachea.
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Date
2013-09
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Abstract
Capparis spinosa (Capparidaceae) dicotyledons from the class of spermaphytes, is a shurb, enduring and woody
plant, typically Mediterranean, largely used in folk medicine in the Mediterranean countries including Algeria.
The aim of the present research is to assess the in vitro effects of aqueous extract of different parts of Capparis
spinosa (leaves, fruits and seeds) on rat trachea in order to establish them as a real source for the isolation of
bioactive compounds with potential use as anti-obstructive or anti-allergic agents. Rings of windpipes of rat
Wistar were isolated, streamlined cut and suspended in organ bath containing 10 ml of Krebs physiological
solution. The addition of Capparis spinosa extracts (0.1, 1 and 10 mg/ml) during the step of contraction by
acetylcholine showed various effects on trachea. Incubation of the windpipe for 30 mn with extracts proves to be
so efficient. The dose of 10 mg/ml showed a significant relaxant effect for fruits and seeds, and constrictor effect
for the leaves. The results showed a potent relaxant effect of the fruit aqueous extract of Capparis spinosa, on rat
trachea, with a dose dependant manner. However, the leaf aqueous extract has a contractive effect. A muscarinic
receptor blockade/stimulation was suggested for caper/leaf extracts.
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Keywords
Medicinal Plants, Capparis spinosa, trachea, aqueous extract, windpipe rings
Citation
BENZIDANE Nadia, CHAREF Noureddine, KRACHE Imane, BAGHIANI Abderrahmane, ARRAR Lekhmici. In Vitro Bronchorelaxant Effects of Capparis Spinosa Aqueous Extracts on Rat Trachea. Journal of Applied Pharmaceutical Science. 2013 Sept; 3(9): 85-88.