In Vitro Evaluation of the Antimicrobial and Antimycobacterial Activities of Solanum guaraniticum A. St.-Hil. Leaves.
Date
2013-09
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Abstract
With the emergence of antimicrobial resistance, it becomes necessary to search for new alternatives for the
treatment of infectious diseases. Solanum guaraniticum is a shrub known as jurubeba or false jurubeba that has
hepatoprotective and antioxidant activities, used in popular medicine for the treatment of various diseases. The
aim of this study was to evaluate the in vitro antimicrobial and antimycobacterial activities of crude extract,
chloroforn, ethyl acetate and butanol fractions from its leaves. Good activities were observed for the ethyl acetate
fraction against Staphylococcus intermedius and Listeria monocytogenes (MIC = 64 μg/mL) and for the crude
extract against Micrococcus luteus (MIC = 32 μg/mL). In general, the extracts showed moderate activity against
Gram-positive bacteria, and were inactive against Gram-negative bacteria and fungi. It was also verified
considerable activity against Mycobacterium smegmatis, mainly by chloroform fraction (MIC = 156 μg/mL).
These results are probably due to the good antioxidant activity and to the presence of high contents of
polyphenols, tannins and alkaloids, metabolites known to possess antimicrobial activity. Studies aiming the
isolation of compounds are necessary in order to know the main component involved in these activities, since the
plant has an antimicrobial potential.
Description
Keywords
Antimicrobial, antimycobacterial, jurubeba, polyphenols, S. guaraniticum.
Citation
Zadra Marina, Piana Mariana, Boligon Aline Augusti, Brum Thiele Faccim De, Rossato Luana, Alves Sydney Hartz, Dalmolin Tanise Vendruscolo, Campos Marli Matiko Anraku De, Athayde Margareth Linde. In Vitro Evaluation of the Antimicrobial and Antimycobacterial Activities of Solanum guaraniticum A. St.-Hil. Leaves. Journal of Applied Pharmaceutical Science. 2013 Sept; 3(9): 19-23.