Antileishmanial, Antimalarial and Antimicrobial activity of the Jamaican ‘Touch-me-not’ sponge Neofibularia nolitangere.
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Date
2013-08
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Abstract
The crude extracts and fractions of the Jamaican sponge Neofibularia nolitangere were examined for biological
activity. The dried animal was extracted successively in three organic solvents (hexane, methylene chloride and
methanol) and tested for their potential as antileishmanial, antimalarial and antimicrobial agents. Fractions of the
crude methylene chloride extract demonstrated notable antimalarial properties giving percentage inhibitions of
87% and 78% respectively for fractions Y4 and Y5 at 20 μg/mL. Fractions Y4 and Z4 showed remarkable
antileishmanial activity inhibiting the growth of the pathogen by 93.31% and 91.77% respectively at 20 μg/mL.
No significant activity was observed in the antimicrobial assays.
Description
Keywords
Neofibularia nolitangere, antileishmanial activity, antimalarial activity, antimicrobial activity
Citation
Thompson Monique N, Gallimore Winklet. Antileishmanial, Antimalarial and Antimicrobial activity of the Jamaican ‘Touch-me-not’ sponge Neofibularia nolitangere. Journal of Applied Pharmaceutical Science. 2013 Aug; 3(8): 80-83.