A sustained release of tablet granules associated with ZnS nanocrystals using Tamarind seed polysaccharide.
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Date
2013-05
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Abstract
Tamarind seed polysaccharide (TSP) isolated from tamarind kernel powder was investigated for sustained release
manners of salicylic acid drug. Tablet granules of salicylic acid were prepared, with two different grades of TSP
and Cross linked TSP and embedded with chemically synthesized ZnS nanocrystals. Five different formulations
made and the drug excipient mixtures were subjected to pre-formulation studies such as physicochemical studies,
in vitro dissolution test, disintegration test, angle of repose and drug content. The physicochemical properties of
tablets were found within the limits. Formulation F1 and F5 containing TSP and Cross linked were found to
release the drug in sustained manner up to 24 hour and were stable under accelerated conditions of temperature
for 6 months since there were no significant changes in drug content and physical parameters. This formulation
was more comfortable to the user due to less erosion, faster and optimum pH of surrounding medium.
Description
Keywords
Tamarind kernel powder, Tamarind Seed Polysaccharide (TSP), ZnS, Sustained Release Matrix Tablets, TEM analysis
Citation
Ganesan Karthikeyan, Rajaram Shyam Kumar, Chinnathambi Arunachalam, Murugesan Veerlakshmi, Muruganantham Kasturiprabha, Amanullah Thoufik Rahuman, Barthelomai Infant Santhose, Chinnasamy Sathishkumar. A sustained release of tablet granules associated with ZnS nanocrystals using Tamarind seed polysaccharide. Journal of Applied Pharmaceutical Science. 2013 May; 3(4 suppl_1): s44-s47.